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This enzyme has the task of combining the amino acids glutamate and cysteine to form gamma-glutamylcysteine (GGC), which is used to produce glutathione (GSH) by the GS enzyme

Disclosures This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

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PEGylation the covalent attachment of polyethylene glycol (PEG) chains via a succinyl linker surrounds the peptide with a steric hydrophilic shield that dramatically increases hydrodynamic radius, reduces renal filtration, and provides protection from proteolytic degradation