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A reduction in liver stiffness but not in liver fat content was shown in subjects who drank more than three cups of coffee a day, thus suggesting that coffee has an antifibrotic effect since caffeine, an adenosine receptor antagonist, reduces fibrogenesis and thus collagen production [37]

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A 2018 study in Obesity journal further confirmed that tesofensine effectively reduces caloric intake, primarily due to its action on appetite centers in the brain

Multitasking in the mitochondrion by the ATP-dependent Lon protease