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Data Human Data A Medicaid cohort linkage study of 1,152 statin-exposed pregnant women compared to 886,996 controls did not find a significant teratogenic effect from maternal use of statins in the first trimester of pregnancy, after adjusting for potential confounders including maternal age, diabetes mellitus, hypertension, obesity, and alcohol and tobacco use using propensity score-based methods

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In vivo experiments showed no abnormalities in liver or kidney function, and local intraocular injection reduced systemic toxicity, indicating its translational medicine potential