The slight potential reduction comes from lower peak concentrations, but this is partially offset by higher trough levels providing more consistent appetite suppression
This triggers Somatostatin, a hormone that inhibits growth hormone secretion, which will significantly blunt or even cancel out the GH pulse from the peptides

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First, subtherapeutic doses (due to potency loss) may fail to suppress appetite effectively, leading users to increase their dose unnecessarily and risk overdose symptoms like severe nausea, vomiting, or hypoglycemia