which are glp 1 drugs IUPHAR review – Glucagon-like peptide-1 (GLP-1) and substance use disorders: An emerging pharmacotherapeutic target GLP-1 and Addiction: Clinical Trials

A pilot trial suggested metformin might reduce cognitive decline in people without diabetes, and a large-scale dementia prevention trial with metformin has been proposed in people without diabetes [49,50,51]

Reducing caloric intake involves setting calorie limits, cutting calories, or restricting certain food types such as dietary fat

Amylin is a pancreatic peptide co-secreted with insulin that plays a key role in postprandial glucose regulation, gastric emptying inhibition, and satiety signaling

These include pericyte degeneration or reduction in pericyte coverage [54, 55], basement membrane alterations [56], and astrocytic end-feet detachment from vascular basement membrane