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Once you puncture the vial, however, you've created a potential entry point for contaminants

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BCMJ 3:138141 Menzel-Soglowek S, Geisslinger G, Brune K (1990) Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein column

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