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Additionally, tirzepatide carries an FDA warning about acute gallbladder disease, which can present with similar abdominal symptoms

One more thing to consider is whether or not oral GLP-1 agonists obtain FDA approval for obesity

Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-2 28 (Figure 1)