Markers of oxidative stress and antioxidant enzyme activity were quantified, including total hydroperoxides (THP), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase
At week 36, the following differences were observed for change in 24-hour diastolic blood pressure from baseline relative to placebo therapy: Tirzepatide 5 mg: -2.0 (95% CI, -3.6 to -0.3) mmHg Tirzepatide 10 mg: -2.9 (95% CI, -4.5 to -1.3) mmHg Tirzepatide 15 mg: -0.5 (95% CI, -2.0 to 1.1) mmHg Further analysis suggested these results were consistent across subgroups defined by clinically relevant factors, including age, sex, BMI, and hypertension-related factors
While it is not FDA-approved for anti-aging or therapeutic use in the U.S., studies suggest that it may help support overall wellness when used under professional supervision
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