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Literature data indicate that PWS patients have lower birth weight and a higher prevalence of preterm delivery and SGA ( Thyroid disorders are quite common in these individuals, and the dysregulation of the hypothalamic-pituitary-thyroid axis is the most frequent cause ( Supplementary Table 1 )

Under medical supervision, both Tesamorelin and Ipamorelin are generally safe for long-term use

doi:10.3389/fnmol.2021.697440 217

The advantages of liquid phase synthesis are mild conditions, simple operation, and easy purification of the product, but there are many reaction steps and low yields