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While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

Project Administration: JKH

To advance translational applications, future studies should focus on: (1) transforming dynamic biomarkers into clinical decision-making tools, such as evaluating early changes in circulating mitochondrial-derived vesicles or oxidative stress markers (e.g., 8isoprostaglandin F2 (8-iso-PGF2))to predict subsequent biochemical and histological responses

2.2 Timeline and variables All patient variables are tracked from the start of the diet to their current follow-up dates