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335,336,337,338 As for non-malignant endothelial cells at regular oxygen concentrations, lactate activates hypoxia-inducible factor 1 (HIF-1) that enhance s basic fibroblast growth factor (bFGF) and vascular endothelial growth factor receptor 2 (VEGFR2) expression, which synergizes with lactate-induced VEGF secretion

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doi: 10.1038/s41573-019-0053-0

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