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114 Additionally, ER can engage directly with other proteins, including those involved in growth signaling pathways, which, in turn, amplifies the transcription of genes that are pivotal for cellular expansion and resistance to apoptosis

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Notably, EPAS1 (which encodes HIF-2) has shown a strong selection signal and is correlated with lower hemoglobin concentrations in Tibetans [2,3,4,5], whereas HIF1A (which encodes HIF-1) has not shown clear signs of selection among Tibetans [3]