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Transcriptional control of TYR expression via MITF MITF serves an indispensable role in melanogenesis as it controls the transcription of TYR and other pigmentation-associated enzymes (46-48)

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Proteomics analysis of MCF7-DoxyR cells provides validating evidence for a predominantly glycolytic phenotype, due to a loss of mitochondrial function In order to further validate our functional observations from metabolic flux analysis, we also performed unbiased label-free proteomics analysis [8]