In addition, because the studies participants had severe hyperglycaemia, metformins glucose-lowering effect may have also been related to changes in peripheral insulin sensitivity, but this was not measured in those studies
These markers included four unidentified lipids, lysophosphatidylcholines (LPCs, 16:0, 18:0, 18:2, and 20:5), phosphatidylethanolamines (PEPs, P-18:0/22:5 and 20.1:20.4), cholesterol, an ether LPC (O-LPC 16:0), triglycerides (TGs, 51:20) and the ketogenic AA threonine [31]
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In the following paragraphs the injury types are described in detail and where available validated with clinical and biological experimental studies