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added LC (0.3, 0.6 and 1.2 mg/mL) to culture media containing swamp buffalo oocytes and noted an improved nuclear maturation rate with a maximum number of metaphase II (MII) oocytes in the 0.3 mg/mL LC-supplemented group [66]

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Many such changes for protein therapeutics (from vials to prefilled syringes or prefilled syringes to pen devices, for example) are considered to enhance patient convenience and ease of use