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10.1164/rccm.201305-0908LE [DOI] [PubMed] [Google Scholar] 122.Hector A, Griese M

When the LMP is not repaired, persistent lysosomal rupture may lead to the massive release of lysosomal contents, cascade hydrolysis of cytoplasmic contents, and extensive cytoplasmic acidification, thus contributing to irreversible cell damage 76

For patients presenting between 4 and 8 hours post-ingestion, serum APAP levels should be measured and plotted on the Revised Rumack-Matthew nomogram to assess toxicity risk

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