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This targeted approach is especially critical for AD, where precise delivery to amyloid plaques and inflamed tissue is necessary to maximize efficacy and minimize systemic toxicity [12]

Alkaloids Nuciferine, an alkaloid extracted from lotus leaves, can directly inhibit ferroptosis by reducing cellular oxidative stress, reducing iron accumulation and preventing lipid peroxidation, thereby preventing FA-induced acute kidney injury [166]

Chemically, it is a tripeptide, which means it is composed of three specific amino acids: cysteine, glycine, and glutamic acid

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