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Micic S, Lalic N, Djordjevic D, Bojanic N, Bogavac-Stanojevic N, Busetto GM, et al

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Traditional herbal ingredients, such as berberine, target LPS synthase in Gram-negative bacteria by downregulating lpxC and lpxD gene expression, thereby reducing LPS production and regulating metabolic pathways (including inhibiting TMAO synthesis and promoting SCFA secretion) while simultaneously repairing the intestinal barrier

An improved understanding of oral l-carnitine metabolism in mammals and the potential involvement of gut microbiotadependent processes is thus of considerable interest