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The trouble is that our reserves run down quickly: hard physical effort, chronic stress, infections, poor sleep and stimulants such as alcohol all lower them

The rationale for this approach was to investigate if GLP-1 signalling could cause metabolic reprograming that would persist after removal of receptor stimulation (Fig

4.4.3 Strategies to prevent persister formation and enable eradication Emergence of persistent fungi can be prevented through methods that support early, proactive intervention rather than waiting until established resistance has developed

These data are preliminary and derive from bioinformatics analyses, but they form the basis for further in vivo studies