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Preservation of Insulin and Glucose Homeostasis Unlike growth hormone, which can cause insulin resistance and elevated blood glucose (diabetogenic effects), AOD-9604 has demonstrated no negative effects on carbohydrate metabolism

NNMT is a cytosolic enzyme that regulates energy balance in adipose tissue

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NAD+ PRECURSORS (NMN, NR, NA) Both approaches enhance NAD+-dependent metabolism but through distinct mechanisms: NAD+ precursors (NMN, NR): Provide substrate for NAD+ synthesis, increasing NAD+ production 5-Amino-1MQ: Inhibits NAD+ depletion by suppressing NNMT, preserving existing NAD+ These approaches are mechanistically complementary