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Cell Tissue Res (2012) 350(1):13541.10.1007/s00441-012-1464-y 42 MoranGWLeslieFCLevisonSEWorthingtonJMcLaughlinJT

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The dose is then increased to 5 mg, with potential further increases by 2.5 mg every 4 weeks up to a maximum of 15 mg, depending on individual response and tolerability

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