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Dharmesh Patel Semaglutide in Heart Failure with Obesity Many patients with heart failure with preserved ejection fraction have obesity

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In addition, ghrelin and desacyl-ghrelin act as potent anti-inflammatory agents in the liver by reducing pro-inflammatory cytokines (like TNF-), inhibiting NF-B signalling and programmed hepatocyte cell death, and suppressing hepatic stellate cell activation [20, 31, 145, 146]