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Notably, though, there was a decreased chance of suicide attempts and completed suicides for patients taking liraglutide and semaglutide

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ADAR1 (A-to-I) is also advancing: multiple preclinical efforts now report small-molecule ADAR1 inhibitors that boost MDA5-dependent IFN signaling and show antitumor activity, while orthogonal data in prostate cancer describe ZYS-1 with in vivo efficacycollectively arguing that pharmacologic ADAR1 blockade is becoming feasible, though clinical translation is still ahead (149)