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The discontinuation was a business decision, and not due to safety or efficacy issues

This imbalance can result in base modifications, abasic sites, and strand breaks (Gonzalez-Hunt et al., 2018

Macrophage polarization, the process by which macrophages adopt either a pro-inflammatory (M1) or anti-inflammatory (M2) state, is crucial in influencing tumor growth, immune evasion, and resistance to therapies in ovarian cancer

These were high-risk patients: More than three quarters of the patients had had a previous myocardial infarction, and nearly one quarter had chronic heart failure. Put another way, these were patients who were primed to suffer a serious cardiovascular event