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1 While traditionally studied in isolation, recent advances reveal extensive crosstalk between these pathways, which coordinate protein turnover, stress responses, and quality control under physiological and pathological conditions

doi: 10.1016/j.sjbs.2020.05.018 115 PonnampalamENKianiASanthiravelSHolmanBWBLauridsenCDunsheaFR

(The weight tends to return when people stop taking the drugs.) In some cases, a persons brain may interpret such dramatic, sudden weight loss as starvation, Hildebrandt said, making people more obsessive about food