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A parallel line of work by Chang and colleagues (J Appl Physiol, 2011) examined cultured rat Achilles tendon fibroblasts and reported increased outgrowth, survival and migration alongside elevated phosphorylation of focal adhesion kinase (FAK) and paxillin, the adaptor pair coupling integrin engagement to cytoskeletal reorganisation

Compound 35 effectively inhibited PGE2 and NO production, with IC 50 values of 0.29 M and 0.61 M, respectively

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Human Evidence To Date Publicly available human data consist of a small 12 patient open label intravesical pilot in women with interstitial cystitis non responsive to prior therapy plus anecdotal or preliminary references to other ongoing studies without published results