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pylori and N-methyl-Nnitro-Nnitrosoguanidine (MNNG), the downstream pathways P53, Wnt, Ras, and mTOR are activated by ROS ( via ROS-triggered ER stress, and promoting the development of gastric cancer ( H pylori CagA produces cells with oxidative DNA damage by inducing spermine oxidase (SMO), and a portion of these cells are apoptosis-resistant and therefore highly susceptible to developing cancer ( H pylori infection
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Moreover, some studies have shown that the ChaC1 protein is significantly upregulated in various adverse conditions, such as diabetes, viral infection and atherosclerosis, providing cells with the amino acid nutrients they need under stressful situations but reducing GSH levels