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In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

order: 25 grams Xi'an Youshuo Biotech Co., Ltd

Preferably, submicron to 250 micron diameter microspheres, are desirable, allowing administration by injection with a standard gauge needle

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide derived from a protective protein found naturally in human gastric juice