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Generic versions of biologics (called biosimilars) require a more complex and lengthy approval process than traditional small-molecule generics

Various structural alterations were made at the N-terminal such as substitution of D-norleucine for L-norleucine, N-acetylation of norleucine, and replacement of norleucine with GABA in order to improve overall stability by reducing susceptibility to aminopeptidases

Two months after stopping the duraglutide, she reported that she saw an eye doctor for a dilated eye exam, and the patient reported that papilledema of the right optic nerve was noted