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Moreover, the large clinical trials did not consider ethnic differences in people from different regions and how the coffee was prepared ( in vitro study showed that the antagonist activity of caffeine has adenosine A2AR-mediated growth-promoting effects on HCC cells associated with the MAPK and NF-kappa B pathways (Wiltberger et al., 2019)

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The antioxidants protect against environmental damage, while folate supports cellular repair and regeneration