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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Kanehisa M., Sato Y., Furumichi M., Morishima K., Tanabe M
1 Introduction In the field of pathology, skin diseases encompass a range of cell death mechanisms, including apoptosis, necrosis, and autophagy, among others ( In a groundbreaking study conducted in 2012, Dixon and colleagues unveiled a remarkable pathway of cell death that is intricately linked to the metabolism of iron, particularly within cancer cells ( Figure 1 ) ( Figure 1 In specific terms, researchers confirmed the presence of ferroptosis in Magnaporthe oryzae , the rice blast fungus, through characteristics such as the accumulation of lipid peroxides detected by optimized fluorescence imaging technology and dependence on iron ions, which is crucial for the developmental cell death of conidia during appressorium maturation
