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In cells, H2O2 is also generated via several enzyme-mediated reactions, such as glycollate oxidase during photorespiration, acyl CoA oxidase during b-oxidation, oxalate oxidase that converts oxalate and oxygen to H2O2 and CO2, and NADPH oxidase (a plasma membrane located enzyme) that transfers electrons from NADPH to molecular oxygen to generate O2- (subsequently converted to H2O2) (Desikan et al., 2003)

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By inhibiting the reuptake of these key neurotransmitters, Tesofensine effectively prolongs their presence in the synaptic cleft