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Blood in the stool or black, tarry stools Fever above 101F (38.3C) or chills Signs of dehydration dizziness, dark urine, very little urination, dry mouth, confusion, racing heart Severe abdominal pain or pain that radiates to your back (potential pancreatitis warning) Vomiting that prevents you from keeping fluids down for more than 12 hours Loose stools lasting more than 7 days without improvement Sudden, unintended weight loss greater than 5% of your body weight in a week Severity decoder: watery, liquid, explosive what each means Stool consistency on Zepbound varies widely

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Lastly, the vast majority of studies examined the effects of GLP-1 receptor agonists on drug self-administration in male animals only