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In addition, cells in mature biofilms exhibit altered gene expression patterns, with up-regulation of drug efflux pumps and stress-response pathways (heat-shock proteins, calcineurin signaling), metabolic shifts resulting in micro-niches (areas with hypoxia or nutrient limitation) that diminish activity from fungicidal drugs (Ramage et al., 2005

Its human safety profile is not established there is no completed human trial

Estos estudios contribuyen a comprender mejor cmo los complejos pptido-metal participan en procesos biolgicos relacionados con la regulacin y mantenimiento de los tejidos