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Wu X, Liu H, Hu Q, Wang J, Zhang S, Cui W, Shi Y, Bai H, Zhou J, Han L, et al

Riboflavin, in the form of flavin adenine dinucleotide (FAD), is a required cofactor for glutathione reductase

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The results indicate that pirAEs constitute a clinically severe and potentially fatal category of ICI-related toxicities, most commonly presenting as immune-related pneumonitis, interstitial lung disease, and respiratory failure