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Clinical protocols in integrative oncology studies commonly involve a detailed baseline assessment of tumour sub-type, receptor status, comorbidities, organ function, and concurrent medications including an organized evaluation of pre-existing and current use of supplements to adjust for possible confounding factors (230)

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In this review, we summarise the dynamic balance between reactive oxygen species (ROS) production and clearance, as well as the characteristics of various forms of cell death induced by ROS, including pyroptosis, apoptosis, necroptosis, autophagy, ferroptosis, cuproptosis, disulfidoptosis, oxeiptosis, and epigenetic regulation of these types of cell death