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GLP-1RAs are generally recommended for patients with T2D whose glycated haemoglobin (HbA 1c ) is above target despite diet, exercise and existing glucose-lowering medication, and GLP-1RAs with proven cardiovascular benefit are also recommended in patients with T2D at elevated cardiovascular risk, regardless of HbA 1c [5, 6]

A patient with specific GLP1R polymorphisms might be a candidate for higher doses, while one with particular FTO variants might benefit from combined GLP-1 and GIP activation

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For short-term storage (under a month), 2C to 8C is recommended