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Inhibition of Nrf2 enhanced the sensitivity of RTECs to ferroptosis caused by high glucose, and upregulating Nrf2 reversed the expression of ferroptosis-related proteins to ameliorate cell injury under high glucose conditions[88]

Peroxisome proliferator-activated receptor alpha activates transcription of the Brown fat uncoupling protein-1 gene

By improving NAD+ status, 5-Amino-1MQ enhances cellular energy production and metabolic flexibilitycritical for patients with metabolic dysfunction or mitochondrial inefficiency