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Jayaraman, and Larry Kershner Journal of the American Chemical Society 1966 88 (14), 3373-3375 DOI : 10.1021/ja00966a034 Mechanistic study of basic hydrolysis of amides supports a two step addition-elimination mechanism

Exploring the middle ear function in patients with a cluster of symptoms including tinnitus, hyperacusis, ear fullness and/or pain

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They have realistic expectations about the side effect profile and are willing to tolerate gastrointestinal discomfort in the early weeks