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Research is ongoing, but experts generally agree that significant weight loss can contribute to reductions in bone mineral density if muscle and bone are not adequately stimulated through exercise

With age, there is reduced bacterial diversity, decreased Bifidobacteria counts (up to 1000-fold lower than in young adults), greater gut permeability, and decreased digestive transit time

In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting