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The effects of severe renal impairment on the pharmacokinetics of edaravone have not been studied Hepatic impairment: No dosage adjustments are necessary in patients with hepatic impairment The multicenter clinical trial for RADICAVA ORS included male and female patients (aged 18-75) in the United States, Canada, France, Germany, Italy, and Japan, and included people of various ethnicities 5 RADICAVA ORS - the ONLY FDA-approved oral form of edaravone - was built on years of clinical research and development a Occurred in 10% of patients on RADICAVA and 2% more frequently than placebo

(1) Synjardy Dosage and Administration Assess renal function before initiating and as clinically indicated

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