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Despite the demonstrable importance of surveillance of lean mass during testing of obesity drug candidates, it is common for only fat mass loss or total body weight loss to be measured or presented in pre-clinical and early clinical trials

Topol's advocacy on the subject led to what The New York Times described as an "unusually public dispute" with the Cleveland Clinic's leadership over ties between the academic institution and the pharmaceutical industry, [18] ultimately leading to Topol's departure after his administrative position as head of their academic program was abolished

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