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In contrast, DUBs appear to be less selective, exhibiting regulatory roles across multiple clock components including PER1, CRY1, and BMAL1

In a hemophilia dog model, there was evidence of AAV integration four years after being treated with canine factor VIII (cFVIII) in an AAV8/9 vector, however, there was no evidence of tumor formation within these dogs that had AAV integration [151]

It is not clear whether glucose metabolism is the cause or the result of PD