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This is adaptive thermogenesis, a survival mechanism that has kept humans alive through famines for millennia

GLP-1 agonists work by mimicking the action of the native hormone GLP-1, which is released after meals and engages a receptor (GLP-1R) that stimulates insulin release, suppresses glucagon, slows gastric emptying, and reduces appetite

[1] [2] The most frequently reported digestive side effects in clinical trials include nausea, diarrhoea, constipation, vomiting, and abdominal discomfort

For example, variants in MC4R (melanocortin-4 receptor) and FTO genes influence not just weight response but also how your muscles consume magnesium and handle sodium shifts during rapid metabolism changes