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For example, the transsynaptic complexes of dystroglycans and neurexins correlate with the function of synaptic transmission [60], neurexins-LRRTMs transsynaptic complexes regulate presynaptic differentiation [61], neurexins-calsyntenins transsynaptic complexes correlate with inhibitory synapse formation and function [62] and neurexins-latrophilins transsynaptic complexes are associated with synaptic excitatory mechanisms Ca 2+ independent release [63]

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Growth hormone stimulates hepatic IGF-1 production by binding to growth hormone receptors on liver cells, triggering intracellular signaling through the JAK2/STAT5 pathway that upregulates IGF-1 gene expression