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Although the reasonable predictions of our model compared to literature values suggest that incorporating realworld data from GLP1RA capsule endoscopy and colonic scintigraphy studies can effectively support PBPK model development for GLP1RAdrug interactions, several limitations must be acknowledged

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Consequently, maintaining the therapeutic effects of GLP-1R agonism requires a long-term dosing regimen, much like medications used for other chronic conditions, such as statins for cholesterol control, ACE inhibitors and beta-blockers for blood pressure, or warfarin for blood thinning

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