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Moreover, the Erysipelotrichaceae family is primarily responsible for the production of acetate and butyrate, based on metatranscriptome profiles ( Coriobacteriaceae family positively correlates with the serum LDL-C levels in mice fed with a high fat diet (HFD) ( BAs mainly exist as primary BAs, chenodeoxycholic acid (CDCA), and cholic acid (CA) before fermentation by gut microbiota, whereas the SBAs, deoxycholic acid (DCA), and lithocholic acid (LCA) are generated by Clostridium and some strains of Lachnospiraceae and Peptostreptococcaceae families in the gut