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The clinical data: exactly how much does retatrutide increase heart rate The most authoritative data comes from the phase 2 randomized controlled trial published in the New England Journal of Medicine (Jastreboff et al.)

Fumarate Hydratase, FH (fumarase): The fumarate hydratase (FH: commonly called fumarase) catalyzed reaction is specific for the trans form of fumarate

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As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, Mounjaro works by mimicking naturally occurring incretin hormones that regulate blood glucose levels, reduce appetite, and slow gastric emptying