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While some patients notice a reduction in appetite within the first few weeks, meaningful improvements in blood sugar control and body weight typically become apparent after 8-12 weeks of consistent use

Intuitively, generation of ROS in this process must be timely and spatially controlled to prevent excessive damage to the DNA: a recent report, in fact, describes a new role for the originally discovered superoxide dismutase, SOD1, that is recruited to the nucleus in response to specific stimuli 142