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Adjudicated MACE-4 events occurred in 109 participants and were not increased on tirzepatide compared with glargine (HR 074, 95% CI 051108)

Discontinuation of medication was established by determining how much medication a patient had on hand on a given day calculated by the amount of medication for a given dispense event and how much was left at the date of the dispense event from previous dispenses

The degree of impact varies widely among individuals based on how much their gastric emptying slows and which specific contraceptive formulation they use